• Data Access Details

    The Taiwan Biobank officially made available the information of community volunteers on September 1, 2014 (information on hospital patients has not yet been released). Currently available data are separated into five categories:
    1. Questionnaire: basic demographic information, personal health activity, living environment, dietary status, family medical history, gender-specific questions, economic status, physical constitution (Chinese traditional medicine perspective), and mini-mental state examination (MMSE).
    2. Physical examination: Height, weight, body fat, waist and hip circumference, blood pressure, pulse, bone density, lung function.
    3. Blood and urine tests:
        (Hematology tests) RBC count, WBC count, platelets, hemoglobin, hematocrit, glycated haemoglobin.
        (Serology tests) Fasting glucose, total cholesterol, triglyceride, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, total bilirubin, albumin, serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase, alpha-fetoprotein, blood urea nitrogen, creatinine, uric acid.
        (Virus tests) hepatitis C virus antibody, hepatitis B virus surface antigen, hepatitis B virus surface antibody, hepatitis B virus core antibody, hepatitis B virus e-antigen.
        (Urine tests) Urine microalbumin.
    4. Biological samples: DNA, blood plasma, urine.
    5. Experimental Data:
        Whole-genome genotyping
        Whole-genome sequencing
        DNA methylation
        HLA typing
        Blood metabolome

    Laboratory Analysis

    The Taiwan Biobank was established as an infrastructure for biomedical research in Taiwan. A large collection of biological specimens, data on environmental exposures and lifestyles, and other related health information have been obtained through large-scale invitation and long-term follow-up of prospective participants. The specimens and information are available to biomedical researchers in Taiwan on an application basis.

    In order to avoid sample depletion and to establish a reference information base of the Taiwanese populace, the Taiwan Biobank also conducts large-scale experiments to collect a variety of biomedical data. These experimental data are then made available to researchers for subsequent analysis, thus avoiding the need for repetitive experimental data collection by individual researchers, which results in substantial savings in valuable research manpower, resources and time for the Taiwanese research community. We are hopeful that the experimental data collected at the Taiwan Biobank will become a solid foundation for medical research, and facilitate biomedical researchers in their quest to find new ways to prevent and treat diseases, thereby improving the health of our people in the future.

    Genomics

    The Taiwan Biobank employs both whole-genome sequencing and whole-genome genotyping to establish a genomic database of the Taiwanese population.

    Whole-Genome Sequencing

    The Biobank employs the Thermo Fisher Ion Proton and Illumina HiSeq platforms. Experiments and analyses with the Thermo Fisher Ion Proton System are entrusted to Yourgene Bioscience, while Illumina HiSeq experiments and analyses are conducted by Genomics Bioscience & Technology. Sequencing of DNA extracted from blood samples generate 90 GB of data with an average coverage of 30x.

    Whole-Genome Genotyping

    Genotyping experiments and subsequent analyses are conducted by the National Center for Genome Medicine, Academia Sinica on a custom Axiom Genome-Wide Array Plate, called the TWB chip, based on technology developed by Affymetrix. The TWB chip contains a selection of 653,000 single-nucleotide polymorphisms (SNPs) sites.

    Taiwan View

    Summary results of whole-genome genotyping and the two whole-genome sequencing platforms are posted online on the Taiwan View website(https://taiwanview.twbiobank.org.tw)and are openly available to both Taiwanese and international researchers. Using the browse and search functions of the database, researchers are able to access background information and allele frequencies of the Taiwanese population. Sequence frequency data are also available for download after completing the free registration.


    Epigenomic

    Methylation Array

    Health GeneTech Corp. has been commissioned to perform experiments and conduct analysis of methylation levels of DNA extracted from blood cells using the Illumina Infinium MethylationEPIC BeadChip. The chip is capable of detecting methylation levels of over 850,000 CpG sites within the human genome.

    Applications for TWB biospecimens/information

    Applications for data and biomaterials release from the community-based cohort have been submitted by researchers from a variety of institutes for a wide range of research purposes, including GWASs, replication and validation of biomarkers, development of diagnostic tools, etc. Selected publications resulting from these applications are listed below:

    Sex Transm Infect.
    (2019)
    Borderline personality disorder is associated with an increased risk of sexually transmitted infections: A nationwide population-based cohort study in Taiwan.(Abstract)
    Chen, S. F.,et al.
    Ann Clin Transl Neurol.
    (2019)
    Clinical and genetic profiles of hereditary transthyretin amyloidosis in Taiwan.(Abstract)
    Chao, H. C.,et al.
    Cancer Cell Int 19: 87.
    (2019)
    Genetic variants in the circadian rhythm pathway as indicators of prostate cancer progression.(Abstract)
    Yu, C. C.,et al.
    Cancer Med.
    (2019)
    Metformin reduces prostate cancer risk among men with benign prostatic hyperplasia: A nationwide population-based cohort study.(Abstract)
    Kuo, Y. J.,et al.
    Int J Hyg Environ Health.
    (2019)
    Association between chronic obstructive pulmonary disease and PM2.5 in Taiwanese nonsmokers.(Abstract)
    Huang, H. C.,et al.
    Scientific Reports
    (2019)
    Germline susceptibility variants impact clinical outcome and therapeutic strategies for stage III colorectal cancer.(Abstract)
    Lin, P. C.,et al.
    Int. J. Mol. Sci.
    (2019)
    Circulating Chemerin Levels, but not the RARRES2 Polymorphisms, Predict the Long-Term Outcome of Angiographically Confirmed Coronary Artery Disease.(Abstract)
    Er, L. K.,et al.
    J Clin Med
    (2019)
    Genome-Wide Copy Number Variation Association Study of Atrial Fibrillation Related Thromboembolic Stroke.(Abstract)
    Hsieh, C. S.,et al.
    Scientific Reports
    (2019)
    Integrative Genome-Wide Association Studies of eQTL and GWAS Data for Gout Disease Susceptibility.(Abstract)
    Lee, M. T.,et al.
    Vox Sang
    (2019)
    Genotyping and serotyping profiles showed weak Jk(a) presentation for previously typed as Jknull donors.(Abstract)
    Wu, P. C.,et al.
    Sci Rep
    (2019)
    Assessing whether the association between rheumatoid arthritis and schizophrenia is bidirectional: A nationwide population-based cohort study.(Abstract)
    Chen, S. F.,et al.
    Clinical Epigenetics
    (2019)
    SOX2 promoter hypermethylation in non-smoking Taiwanese adults residing in air pollution areas.(Abstract)
    Tantoh, D. M.,et al.
    Acta Cardiol Sin
    (2019)
    The Utilization of Stress Tests Prior to Percutaneous Coronary Intervention for Stable Coronary Artery Disease in Taiwan.(Abstract)
    Yang, H. P.,et al.
    Psychiatry Research
    (2019)
    Functional analyses and effect of DNA methylation on the EGR1 gene in patients with schizophrenia.(Abstract)
    Hu, T. M.,et al.
    DNA Repair
    (2019)
    Polymorphisms of the DNA repair gene EXO1 modulate cognitive aging in old adults in a Taiwanese population.(Abstract)
    Lin, E.,et al.
    Genes
    (2019)
    The Interaction between Sex and Hyperlipidemia on Gout Risk Is Modulated by HLA-B Polymorphic Variants in Adult Taiwanese.(Abstract)
    Hsu, T. W.,et al.
    Mov Disord
    (2019)
    A clinical and genetic study of early-onset and familial parkinsonism in taiwan: An integrated approach combining gene dosage analysis and next-generation sequencing.(Abstract)
    Lin, C. H.,et al.
    Circ J.
    (2019)
    Common Genetic Variants on Bone Morphogenetic Protein Receptor Type IB (BMPR1B) Gene Are Predictive for Carotid Intima-Media Thickness.(Abstract)
    Wu, Y. J.,et al.
    QJM
    (2019)
    Gender Difference in Clinical and Genetic Characteristics of Brugada Syndrome: SADS-TW BrS Registry.(Abstract)
    Chen, C. J.,et al.
    Frontiers in Genetics
    (2019)
    Genome-Wide Gene-Environment Interaction Analysis Using Set-Based Association Tests.(Abstract)
    Lin, W. Y.,et al.
    Orphanet J Rare Dis.
    (2019)
    Genotypic and phenotypic correlations of biotinidase deficiency in the Chinese population.(Abstract)
    Hsu, R. H.,et al.
    Nutrients
    (2019)
    The Impact of Aerobic Exercise and Badminton on HDL Cholesterol Levels in Adult Taiwanese.(Abstract)
    Nassef, Y.,et al.
    J Bone Miner Res.
    (2019)
    A meta-analysis of genome-wide association studies identifies three loci associated with stiffness index of the calcaneus.(Abstract)
    Lu, H. F.,et al.
    Aging Dis.
    (2019)
    REST rs3796529 Genotype and Rate of Functional Deterioration in Alzheimer's Disease.(Abstract)
    Huang, P.,et al.
    Sci Rep.
    (2018)
    Body mass index modulates the association between CDKAL1 rs10946398 variant and type 2 diabetes among Taiwanese women.(Abstract)
    Nfor ON, Wu MF, Lee CT et al.
    Exp Ther Med.
    (2018)
    Identification of mutations in SLC4A1, GP1BA and HFE in a family with venous thrombosis of unknown cause by next-generation sequencing.(Abstract)
    Chang WA, Sheu CC, Liu KT et al.
    Clin Oral Investig.
    (2018)
    Functional variant of CHI3L1 gene is associated with neck metastasis in oral cancer.(Abstract)
    Su CW, Chen MK, Hung WC et al.
    Int J Med Sci.
    (2018)
    Impact of ADAM10 gene polymorphisms on hepatocellular carcinoma development and clinical characteristics.(Abstract)
    Shiu JS, Hsieh MJ, Chiou HL et al.
    Brief Bioinform.
    (2018)
    Polygenic approaches to detect gene-environment interactions when external information is unavailable.(Abstract)
    Lin WY, Huang CC, Liu YL et al.
    Neurobiol Aging.
    (2018)
    Genetic analysis of ANXA11 variants in a Han Chinese cohort with amyotrophic lateral sclerosis in Taiwan.(Abstract)
    Tsai PC, Liao YC, Jih KY et al.
    Int J Med Sci.
    (2018)
    IGF1 Gene Is Associated With Triglyceride Levels In Subjects With Family History Of Hypertension From The SAPPHIRe And TWB Projects.(Abstract)
    Wang WC, Chiu YF, Chung RH et al.
    Nitric Oxide.
    (2018)
    Associations of genetic variations of the endothelial nitric oxide synthase gene and environmental carcinogens with oral cancer susceptibility and development.(Abstract)
    Su CW, Chien MH, Lin CW et al.
    Int J Med Sci.
    (2018)
    Impact of matrix metalloproteinase-11 gene polymorphisms upon the development and progression of hepatocellular carcinoma.(Abstract)
    Wang B, Hsu CJ, Lee HL et al.
    Int J Med Sci.
    (2018)
    Variations in the AURKA Gene: Biomarkers for the Development and Progression of Hepatocellular Carcinoma.(Abstract)
    Wang B, Hsu CJ, Chou CH et al.
    Exp Ther Med.
    (2018)
    Hematopoietically expressed homeobox gene is associated with type 2 diabetes in KK Cg-Ay/J mice and a Taiwanese Han Chinese population.(Abstract)
    Lu CC, Chen YT, Chen SY et al.
    Arthritis Res Ther.
    (2018)
    Next-generation sequencing profiling of mitochondrial genomes in gout.(Abstract)
    Tseng CC, Chen CJ, Yen JH et al.
    Sci Rep.
    (2018)
    Gene-based analysis of genes related to neurotrophic pathway suggests association of BDNF and VEGFA with antidepressant treatment-response in depressed patients.(Abstract)
    Kao CF, Liu YL, Yu YW et al.
    J Atheroscler Thromb.
    (2018)
    Associations of Common Genetic Variants on IL-17 Genes and Carotid Intima-Media Thickness.(Abstract)
    Wu TW, Chou CL, Chen YC et al.
    Ultrasound Obstet Gynecol.
    (2018)
    SMAD2 as a risk locus for human left atrial isomerism detected by mother-fetus-pair exome sequencing and image studies including fetal ultrasound.(Abstract)
    Shih JC, Ma GC, Cheng WC et al.
    Clin Genet.
    (2018)
    Mutational analysis of CCM1, CCM2 and CCM3 in a Han Chinese cohort with multiple cerebral cavernous malformations in Taiwan.(Abstract)
    Jih KY, Chung CP, Chang YY et al.
    J Viral Hepat.
    (2018)
    Hepatitis B virus infection in Taiwan: The role of NTCP rs2296651 variant in relation to sex.(Abstract)
    Nfor ON, Wu MF, Debnath T et al.
    Sci Rep.
    (2018)
    ABCG2 contributes to the development of gout and hyperuricemia in a genome-wide association study.(Abstract)
    Chen CJ, Tseng CC, Yen JH et al.
    J Formos Med Assoc.
    (2018)
    A CRYBB2 mutation in a Taiwanese family with autosomal dominant cataract.(Abstract)
    Ching YH, Yeh JI, Fan WL et al.
    Oncotarget.
    (2017)
    Detection of susceptibility loci on APOA5 and COLEC12 associated with metabolic syndrome using a genome-wide association study in a Taiwanese population.(Abstract)
    Lin E, Kuo PH, Liu YL et al.
    Oncotarget.
    (2017)
    Effects of circadian clock genes and environmental factors on cognitive aging in old adults in a Taiwanese population.(Abstract)
    Lin E, Kuo PH, Liu YL et al.
    Sci Rep.
    (2017)
    Transforming growth factor-β signaling pathway-associated genes SMAD2 and TGFBR2 are implicated in metabolic syndrome in a Taiwanese population.(Abstract)
    Lin E, Kuo PH, Liu YL et al.
    Oncotarget.
    (2017)
    Urine miR-21-5p as a potential non-invasive biomarker for gastric cancer.(Abstract)
    Kao HW, Pan CY, Lai CH et al.
    BMC Neurol.
    (2017)
    Intrafamilial phenotypic heterogeneity in a Taiwanese family with a MAPT p.R5H mutation: a case report and literature review.(Abstract)
    Lin HC, Lin CH, Chen PL et al.
    Neurobiol Aging.
    (2017)
    Investigating CCNF mutations in a Taiwanese cohort with amyotrophic lateral sclerosis.(Abstract)
    Tsai PC, Liao YC, Chen PL et al.
    BMC Neurol.
    (2017)
    Identification of VPS35 p.D620N mutation-related Parkinson's disease in a Taiwanese family with successful bilateral subthalamic nucleus deep brain stimulation: a case report and literature review.(Abstract)
    Chen YF, Chang YY, Lan MY et al.
    Oncotarget.
    (2017)
    A functional variant at the miRNA binding site in HMGB1 gene is associated with risk of oral squamous cell carcinoma.(Abstract)
    Lin CW, Chou YE, Yeh CM et al.
    Oncotarget.
    (2017)
    rs2841277 (PLD4) is associated with susceptibility and rs4672495 is associated with disease activity in rheumatoid arthritis.(Abstract)
    Chen WC, Wang WC, Okada Y et al.
    J Affect Disord.
    (2017)
    Evaluation of the interaction between genetic variants of GAD1 and miRNA in bipolar disorders.(Abstract)
    Chung YE, Chen SC, Chuang LC et al.
    Hepatology.
    (2017)
    Human Leukocyte Antigen Variants and Risk of Hepatocellular Carcinoma Modified by HCV Genotypes: A Genome-wide Association Study.(Abstract)
    Lee MH, Huang YH, Chen HY et al.
    BMC Genomics.
    (2017)
    Genome-wide copy number variation analysis identified deletions in SFMBT1 associated with fasting plasma glucose in a Han Chinese population.(Abstract)
    Chung RH, Chiu YF, Hung YJ et al.
    Sci Rep.
    (2017)
    A novel missense variant in the nuclear localization signal of POU4F3 causes autosomal dominant non-syndromic hearing loss.(Abstract)
    Lin YH, Lin YH, Lu YC et al.
    Cancer.
    (2017)
    Genome-wide association analysis identifies a GLUL haplotype for familial hepatitis B virus-related hepatocellular carcinoma.(Abstract)
    Lin YY, Yu MW, Lin SM et al.
    Sci Rep.
    (2017)
    Association of human height-related genetic variants with familial short stature in Han Chinese in Taiwan.(Abstract)
    Lin YJ, Liao WL, Wang CH et al.
    Clin Cancer Res.
    (2017)
    The c.1085A>G genetic variant of CSF1R gene regulates tumor immunity by altering the proliferation, polarization, and function of macrophages.(Abstract)
    Yeh YM, Hsu SJ, Lin PC et al.
    Int J Med Sci.
    (2017)
    Impacts of CCL4 gene polymorphisms on hepatocellular carcinoma susceptibility and development.(Abstract)
    Wang B, Chou YE, Lien MY et al.
    Oncotarget.
    (2017)
    Germline variations at JAK2, TERT, HBS1L-MYB and MECOM and the risk of myeloproliferative neoplasms in Taiwanese population.(Abstract)
    Chiang YH, Chang YC, Lin HC et al.
    PLoS One.
    (2017)
    Effects of circadian clock genes and health-related behavior on metabolic syndrome in a Taiwanese population: Evidence from association and interaction analysis.(Abstract)
    Lin E, Kuo PH, Liu YL et al.
    PLoS One.
    (2017)
    Combined effect of genetic polymorphisms of AURKA and environmental factors on oral cancer development in Taiwan.(Abstract)
    Chou CH, Chou YE, Chuang CY et al.
    PLoS One.
    (2017)
    The ADAMTS9 gene is associated with cognitive aging in the elderly in a Taiwanese population.(Abstract)
    Lin E, Tsai SJ, Kuo PH et al.
    Oncotarget.
    (2017)
    Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population.(Abstract)
    Lin E, Tsai SJ, Kuo PH et al.
    Dement Geriatr Cogn Disord.
    (2017)
    The rs1277306 Variant of the REST Gene Confers Susceptibility to Cognitive Aging in an Elderly Taiwanese Population.(Abstract)
    Lin E, Tsai SJ, Kuo PH et al.
    Sci Rep.
    (2016)
    Association and interaction of APOA5, BUD13, CETP, LIPA and health-related behavior with metabolic syndrome in a Taiwanese population.(Abstract)
    Lin E, Tsai SJ, Kuo PH et al.
    Hum Mol Genet.
    (2016)
    Population structure of Han Chinese in the modern Taiwanese population based on 10,000 participants in the Taiwan Biobank project.(Abstract)
    Chen CH, Yang JH, Chiang CW et al.
    Hum Genet.
    (2016)
    Identification of susceptibility gene associated with female primary Sjögren's syndrome in Han Chinese by genome-wide association study.(Abstract)
    Song IW, Chen HC, Lin YF et al.
    Gut.
    (2015)
    The rs2296651 (S267F) variant on NTCP (SLC10A1) is inversely associated with chronic hepatitis B and progression to cirrhosis and hepatocellular carcinoma in patients with chronic hepatitis B.(Abstract)
    Hu HH, Liu J, Lin YL et al.
    Medicine (Baltimore).
    (2015)
    Polymorphisms and Plasma Levels of Tissue Inhibitor of Metalloproteinase-3: Impact on Genetic Susceptibility and Clinical Outcome of Oral Cancer.(Abstract)
    Su CW, Huang YW, Chen MK et al.
    Neurobiol Aging.
    (2014)
    ABCA7 gene and the risk of Alzheimer's disease in Han Chinese in Taiwan.(Abstract)
    Liao YC, Lee WJ, Hwang JP et al.
    PLoS One.
    (2014)
    Single nucleotide polymorphisms associated with colorectal cancer susceptibility and loss of heterozygosity in a Taiwanese population.(Abstract)
    Yang CY, Lu RH, Lin CH et al.